Interaction Network too Large to Display
| Score | Dataset | |||
|---|---|---|---|---|
| CDYL2 | LMO3 | 0.817 | HI-III null | |
| CDYL2 | HSF2BP | 0.814 | HI-III null | |
| CDYL2 | DVL3 | 0.819 | HI-III null | |
| CDYL2 | NXF1 | 0.785 | HI-III null | |
| CDYL2 | PRMT5 | Lit-BM | ||
| CDYL2 | ZBTB9 | 0.822 | HI-III null | |
| CDYL2 | SPANXN2 | 0.810 | HI-III null | |
| PRMT5 | PRMT5 | Lit-BM | ||
| HSF2BP | HSF2BP | Lit-BM | ||
| HSF2BP | NXF1 | 0.920 | HI-III null | |
CDYL2
Chromodomain Y-like protein 2
GeneList
AlphaFold
NCBI Gene
Human Protein Atlas
Ensembl
Gene Cards
Uniprot
UCSC Genome BrowserInteractions in Network: 7
Interactions in Database: 7
N/A
SPANXN2
Sperm protein associated with the nucleus on the X chromosome N2
Interactions in Network: 1
Interactions in Database: 51
N/A
ZBTB9
Zinc finger and BTB domain-containing protein 9
Interactions in Network: 2
Interactions in Database: 32
May be involved in transcriptional regulation.
NXF1
Nuclear RNA export factor 1
Interactions in Network: 3
Interactions in Database: 69
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
DVL3
Segment polarity protein dishevelled homolog DVL-3
Interactions in Network: 2
Interactions in Database: 146
Involved in the signal transduction pathway mediated by multiple Wnt genes.
HSF2BP
Heat shock factor 2-binding protein
Interactions in Network: 3
Interactions in Database: 293
May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).
PRMT5
Protein arginine N-methyltransferase 5
Interactions in Network: 2
Interactions in Database: 27
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates TP53; methylation might possibly affect TP53 target gene specificity (PubMed:19011621).
LMO3
LIM domain only protein 3
Interactions in Network: 1
Interactions in Database: 119
N/A
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